Unfortunately, the solution stability of this product has not been determined. However, historical information on a previously deleted option indicates that solutions in water may be stored for up to 1 month and solutions in DMSO may be stored for up to 6 months at - 20°C, in aliquots. Avoid repeated freeze/thaw cycles.
PZ0178
PHA 767491 hydrochloride
≥98% (HPLC)
Synonym(s):
1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H11N3O · xHCl
CAS Number:
Molecular Weight:
213.24 (free base basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
off-white to yellow
solubility
H2O: >25 mg/mL
SMILES string
Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3
InChI
1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
InChI key
IMVNFURYBZMFDZ-UHFFFAOYSA-N
Application
Biochem/physiol Actions
PHA 767491 serves as a potential anticancer drug.[3] It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.[4]
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9.
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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시약 보관 온도 문의드립니다. H2O에 녹인 후에 -20'C에 보관하면 되는걸까요?
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