TRPC3 (transient receptor potential-canonical 3) belongs to TRPC family. It is present in sperm. It is located on chromosome 4q27.
Immunogen
a 14 amino acid peptide from near the carboxy-terminus of human TRPC3.
Application
Anti-TRPC3 has been used in immunofluorescent staining.
Biochem/physiol Actions
TRPC3 (transient receptor potential-canonical 3) participates in motility and capacitation of sperm. It is responsible for the proliferation of ovarian cancer cell in vitro and in vivo.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3905.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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FSH enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3
Tao X, et al.
Endocrine-Related Cancer, 20(3), 415-429 (2013)
Transient receptor potential-canonical 3 modulates sperm motility and capacitation-associated protein tyrosine phosphorylation via [Ca2+]i mobilization
Ru Y, et al.
Acta biochimica et biophysica Sinica, 47(6), 404-413 (2015)
TRP channels in endothelial function and dysfunction
Kwan HY, et al.
Biochimica et Biophysica Acta, 1772(8), 907-914 (2007)
Acta biochimica et biophysica Sinica, 47(6), 404-413 (2015-04-26)
Ca(2+) signaling is pivotal for sperm maturation, including the processes of motility, capacitation, and the acrosome reaction. As a Ca(2+) conductor, transient receptor potential-canonical 3 (TRPC3) plays an important role in somatic cells. However, the function of TRPC3 in sperm
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