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MAK314

Sigma-Aldrich

Sialic Acid Assay Kit

sufficient for 100 colorimetric or fluorometric tests

Synonym(s):

Sialic Acid (NANA) Assay Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

usage

sufficient for 100 colorimetric or fluorometric tests

detection method

colorimetric
fluorometric

relevant disease(s)

cancer; cardiovascular diseases; hematological disorder

storage temp.

−20°C

Related Categories

General description

Sialic Acid is a general name for nine carbon acidic sugars with N- or O-substituted derivatives. The most common member of these sugars is N-acetylneuraminic acid (NANA). They are associated with carbohydrates and are localized on cell membranes. Sialic acid is widely distributed throughout mammalian tissues and fluids including serum. Sialylated oligosaccharides have been shown to exhibit antiviral properties and are also known to influence blood coagulation and cholesterol levels. The sialic acid level in body fluids is also an important marker for diagnosing cancer.

Application


  • Evaluation of serum total sialic acid in moderate COVID-19 patients with and without gastrointestinal tract manifestations.: The study measures serum sialic acid levels in COVID-19 patients to understand the disease′s impact on the gastrointestinal tract (Haroun et al., 2022).

Suitability

Suitable for the quantitative determination of free and total sialic acid (NANA) and evaluation of drug effects on sialic acid in serum, plasma, saliva, milk etc.

Principle

This sialic acid assay uses an improved Warren method, in which sialic acid is oxidized to formylpyruvic acid. This reacts with thiobarbituric acid to form a pink colored product. The colorimetric (549nm)/fluorimetric (λex = 555nm/λem = 585nm) product is directly proportional to sialic acid concentration in the sample.

Signal Word

Danger

Hazard Statements

H290,H314,H335,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Salivary total sialic acid levels increase in breast cancer patients: a preliminary study.
Ozturk L K, et al.
Medicinal Chemistry, 7(5), 443-447 (2011)
Sialic Acids
Varki A, et al.
Essentials Of Glycobiology. 2nd Edition. (2009)
Sialic acids: fascinating sugars in higher animals and man.
Schauer R.
Zoology (Jena, Germany), 107(1), 49-64 (2004)
Alice J Stelfox et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(43), 21514-21520 (2019-10-09)
The bat-borne paramyxovirus, Sosuga virus (SosV), is one of many paramyxoviruses recently identified and classified within the newly established genus Pararubulavirus, family Paramyxoviridae The envelope surface of SosV presents a receptor-binding protein (RBP), SosV-RBP, which facilitates host-cell attachment and entry.

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