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Metyrapone

Name: Metyrapone
Brand: SIGMA

≥98% (HPLC), glucocorticoid synthesis inhibitor, solid

Synonym(s):

2-Methyl-1,2-di-3-pyridyl-1-propanone, Metyrapone, Su-4885

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₄N₂O

CAS Number:

54-36-4

Molecular Weight:

226.27

NACRES:

NA.77

PubChem Substance ID:

329817949

UNSPSC Code:

51111800

EC Number:

200-206-2

MDL number:

MFCD00006397

Beilstein/REAXYS Number:

163023

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Product Name

Metyrapone, ≥98% (HPLC), solid

sterility

non-sterile

Quality Segment

100

assay

≥98% (HPLC)

form

solid

technique(s)

toxicology assay: suitable

mp

52-55 °C (lit.)

solubility

H₂O: <2 mg/mL, DMSO: >20 mg/mL

originator

Novartis

shipped in

ambient

storage temp.

room temp

SMILES string

CC(C)(c1cccnc1)C(=O)c2cccnc2

InChI

1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3

InChI key

FJLBFSROUSIWMA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item	D9069	T3577	1443001
Sigma-Aldrich M2696 Metyrapone	Sigma-Aldrich D9069 N-Desmethyltamoxifen HCl	Sigma-Aldrich T3577 Tolperisone hydrochloride	USP 1443001 Metyrapone
form solid	form solid	form solid	form -
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
technique(s) toxicology assay: suitable	technique(s) inhibition assay: suitable	technique(s) -	technique(s) -
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. -
solubility H₂O: <2 mg/mL, DMSO: >20 mg/mL	solubility DMSO: ≥20 mg/mL	solubility H₂O: >20 mg/mL	solubility -

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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