![[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/824/913/b005e93b-3a90-4b0b-8842-a1f66f419ccd/640/b005e93b-3a90-4b0b-8842-a1f66f419ccd.png)
![[D-Ala6]-LH-RH acetate salt hydrate ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/222/268/0818f701-a831-440e-9dd2-5f851035c421/640/0818f701-a831-440e-9dd2-5f851035c421.png)
The shelf-life of the stock solution for this product was not determined in-house for any storage temperature. It should be empirically determined by the end-user, with reference to published literature for possible citations.
L4513
[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate
[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate
≥97% (HPLC), powder
Synonym(s):
Ethylamide Acetate, Ethylamide Acetate Salt, des-Gly¹⁰ LH-RH
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About This Item
Empirical Formula (Hill Notation):
C56H78N16O12 · xC2H4O2 · yH2O
Molecular Weight:
1167.32 (anhydrous free base basis)
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
Pricing and availability is not currently available.
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Quality Level
Assay
≥97% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6
InChI
1S/C56H78N16O12.C2H4O2.H2O/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38;1-2(3)4;/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61);1H3,(H,3,4);1H2/t31-,38+,39+,40+,41+,42+,43+,44+,45+;;/m1../s1
InChI key
YEEHIOYEWOESQR-PFHUABGLSA-N
Gene Information
mouse ... GNRH1(2796) , GNRHR(2798)
rat ... GNRH1(14714) , GNRHR(14715)
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Amino Acid Sequence
Glp-His-Trp-Ser-Tyr-Ala-Leu-Arg-Pro-NHEt
Application
[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate has been used:
- as an luteinizing hormone-releasing hormone (LHRH) agonist to synchronize a cohort of females rats[1]
- to synchronize naturally cycling rats[2]
- to induce ovulation[3][4] as a gonadotropin-releasing hormone (GnRH) analogue and as a supplement in Galap extender to dilute qualified ejaculate[5]
Biochem/physiol Actions
Potent LH-RH agonist in rats and mice; reversibly delays sexual maturation in rats, stimulates spawning activity in fish. GnRH ( gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands.[6][7][8] Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.[7]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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After dissolution with water, how long can we store the aliquots at -20°C ?
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Come conservarlo una volta risospeso?
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This product may be dissolved in water at 1 mg/mL. Stock solutions are stored in aliquots at -20 °C. Avoid repeated freeze/thaw cycles.
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