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HPA069328

Sigma-Aldrich

Anti-MT-CO1 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

COI, COX1, MTCO1

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunohistochemistry: 1:20- 1:50

isotype

IgG

immunogen sequence

LIRAELGQPGNLLGNDHIYNVIV

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MT-CO1(4512)

General description

Mitochondrially encoded cytochrome c oxidase I (MT-CO1) is also called cytochrome c oxidase subunit 1 (COX1). It is a core component of cytochrome c oxidase complex and is assembled in the mitochondrial organelle. MT-CO1 is encoded in the mitochondrial genome.

Immunogen

mitochondrially encoded cytochrome c oxidase I

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

Cytochrome c oxidase subunit 1 (COX1) coordinates with mitochondrial translation regulation assembly intermediate of cytochrome c oxidase (MITRAC) complex for the incorporation of cytochrome c oxidase complex on to the inner membrane. A frameshift mutation in MT-CO1 resulting in premature stop codon is implicated in severe progressive encephalomyopathy. Missense mutations in MT-CO1 is associated with premature ovarian failure. A mutation in the MT-CO1 gene eliminates stop codon and the defective protein contributes to leber hereditary optic neuropathy.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST88517

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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MITRAC7 acts as a COX1-specific chaperone and reveals a checkpoint during cytochrome c oxidase assembly
Dennerlein S, et al.
Cell Reports, 12(10), 1644-1655 (2015)
Increased incidence of mitochondrial cytochrome C oxidase 1 gene mutations in patients with primary ovarian insufficiency
Zhen X, et al.
PLoS ONE, 10(7), e0132610-e0132610 (2015)
Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance
Dennerlein S and Rehling P
Journal of Cell Science, 128(5), 833-837 (2015)
The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis
Lorenzi I, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1865(2), 323-333 (2018)
A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I.
Brown MD, et al.
American Journal of Human Genetics, 51(2), 378-385 (1992)

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