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D9250

2′-Deoxyguanosine 5′-diphosphate sodium salt

≥90% (HPLC), powder

Synonym(s):

dGDP

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About This Item

Empirical Formula (Hill Notation):
C10H15N5O10P2 · xNa+
CAS Number:
102783-74-4
Molecular Weight:
427.20 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
24894274
NACRES:
NA.51
MDL number:
MFCD00057075
Assay:
≥90% (HPLC)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
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Product Name

2′-Deoxyguanosine 5′-diphosphate sodium salt, ≥90% (HPLC)

Quality Level

200

assay

≥90% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3CC(O)C(COP(O)(=O)OP(O)(O)=O)O3)c2N1

InChI

1S/C10H15N5O10P2.Na.H/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20;;/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17);;

InChI key

VLWIICGGBFZYEZ-UHFFFAOYSA-N

General description

2′-Deoxyguanosine 5′-diphosphate (dGDP) is a nucleotide with guanine base, deoxyribose and two phosphate.[1]

Application

2′-Deoxyguanosine 5′-diphosphate (dGDP) is used as a substrate of dGDP (nucleoside diphosphate) kinase (2.7.4.6) or pyruvate kinase to produce dGTP in support of DNA biosynthesis. dGDP is used as a substrate to study the kinetics of glycoprotein (gp) 1.7 expressed by bacteriophage T7.
2′-Deoxyguanosine 5′-diphosphate sodium salt has been used as a xanthosine 5′-monophosphate analog and xanthine phosphoribosyl transferase inhibitor in kinetic studies.[2]

Biochem/physiol Actions

2′-Deoxyguanosine 5′-diphosphate (dGDP) inhibits xanthine phosphoribosyl transferase (XPRT) and hypoxanthine-guanine phosphoribosyl transferase (HGPRT).[1]

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2′-Deoxyguanosine 5′-diphosphate sodium salt ≥90% (HPLC)

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Sigma-Aldrich

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Sigma-Aldrich

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Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

200

assay

≥90% (HPLC)

assay

≥90% (HPLC)

assay

≥96%

assay

≥95% (HPLC)

form

powder

form

powder

form

powder

form

powder

solubility

water: 50 mg/mL, clear, colorless

solubility

water: 5 mg/mL, clear, colorless

solubility

-

solubility

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000276055
0000276055
SLBW0466
SLBV0081
SLBF8401V

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Ngoc Q Tran et al.
Molecular microbiology, 77(2), 492-504 (2010-05-26)
Gene 1.7 of bacteriophage T7 confers sensitivity of both phage T7 and its host Escherichia coli to dideoxythymidine (ddT). We have purified the product of gene 1.7, gp1.7. It exists in two forms of molecular weight 22,181 and 17,782. Only
Ngoc Q Tran et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(27), 9373-9378 (2008-07-05)
Bacteriophage T7 DNA polymerase efficiently incorporates dideoxynucleotides into DNA, resulting in chain termination. Dideoxythymidine (ddT) present in the medium at levels not toxic to Escherichia coli inhibits phage T7. We isolated 95 T7 phage mutants that were resistant to ddT.
Jiande Gu et al.
Nucleic acids research, 35(15), 5165-5172 (2007-07-31)
The 2'-deoxyguanosine-3',5'-diphosphate, 2'-deoxyadenosine-3',5'-diphosphate, 2'-deoxycytidine-3',5'-diphosphate and 2'-deoxythymidine-3',5'-diphosphate systems are the smallest units of a DNA single strand. Exploring these comprehensive subunits with reliable density functional methods enables one to approach reasonable predictions of the properties of DNA single strands. With these
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Global Trade Item Number

SKUGTIN
D9250-25MG04061833590508
D9250-100MG04061833007013

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