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Calcium Ionophore A23187 hemimagnesium salt

Name: Calcium Ionophore A23187 hemimagnesium salt
Brand: SIGMA

Synonym(s):

A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₃₆Mg_0.5N₃O₆

CAS Number:

72124-77-7

Molecular Weight:

534.77

UNSPSC Code:

12352202

NACRES:

NA.77

PubChem Substance ID:

24893158

MDL number:

MFCD00151203

Beilstein/REAXYS Number:

6765085

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Properties

sterility

non-sterile

Quality Segment

200

form

powder

antibiotic activity spectrum

Gram-positive bacteria, fungi

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(=O)O[Mg]OC(=O)c6c(NC)ccc7oc(C[C@H]8O[C@@]9(CC[C@H]8C)O[C@@H]([C@H](C)C[C@H]9C)[C@H](C)C(=O)c%10ccc[nH]%10)nc67

InChI

1S/2C29H37N3O6.Mg/c2*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;/h2*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);/q;;+2/p-2/t2*15-,16-,17-,18-,22-,27+,29+;/m11./s1

InChI key

XBWKBTZDBYFEMH-UIOMRPQBSA-L

Description

Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. Used to study effects of elevated intracellular calcium on mitochondrial function and intrinsic apoptosis.

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This Item	100107	P3032	51269
Sigma-Aldrich C9400 Calcium Ionophore A23187 hemimagnesium salt	Sigma-Aldrich 100107 4-Bromo-calcium Ionophore A23187	Sigma-Aldrich P3032 Penicillin G sodium salt	Sigma-Aldrich 51269 Dihydroxyacetone phosphate hemimagnesium salt hydrate
description -	description Brominated analog of the widely used cation ionophore A23187. Non-fluorescent and therefore suitable for use in the presence of fluorescent or metal-chelating probes.	description powder, BioReagent, suitable for cell culture	description ≥95% (TLC)
antibiotic activity spectrum Gram-positive bacteria, fungi	antibiotic activity spectrum -	antibiotic activity spectrum Gram-positive bacteria	antibiotic activity spectrum -
mode of action cell membrane \| interferes	mode of action -	mode of action cell wall synthesis \| interferes	mode of action -
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
form powder	form solid	form powder	form -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
sterility non-sterile	sterility -	sterility -	sterility -