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B2938

Sigma-Aldrich

BEPP monohydrochloride

≥98% (HPLC)

Synonym(s):

1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H23N3O2 HCl
CAS Number:
455311-98-5
Molecular Weight:
409.91
MDL number:
MFCD00964481
UNSPSC Code:
12352200
PubChem Substance ID:
329773209
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24

InChI

1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H

InChI key

KDMXJFUGIDGZQL-UHFFFAOYSA-N

Biochem/physiol Actions

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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