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Sigma-Aldrich

Betaine

BioUltra, ≥99.0% (NT)

Synonym(s):

(Carboxymethyl)trimethylammonium inner salt, Oxyneurine, Trimethylglycine

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About This Item

Linear Formula:
(CH3)3N+CH2COO-
CAS Number:
107-43-7
Molecular Weight:
117.15
Beilstein:
3537113
EC Number:
203-490-6
MDL number:
MFCD00012123
UNSPSC Code:
41116107
PubChem Substance ID:
57651874
NACRES:
NA.25

product line

BioUltra

Assay

≥99.0% (NT)

impurities

insoluble matters, passes filter test

solubility

methanol: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤200 mg/kg
sulfate (SO42-): ≤200 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤100 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

absorption

≤0.05 at 280 nm in methanol at 1 M
≤0.09 at 260 nm in methanol at 1 M

SMILES string

C[N+](C)(C)CC([O-])=O

InChI

1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

InChI key

KWIUHFFTVRNATP-UHFFFAOYSA-N

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General description

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

Betaine has been used in reverse transcription to increase the thermal stability of proteins and to destabilize the DNA helix.

Biochem/physiol Actions

Betaine has been shown to increase S-adenosylmethionine (SAM) levels and hence, may have a role in diminishing hepatic steatosis. It is an osmolyte which protects cells against environmental stress.
End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Full-length RNA-seq from single cells using Smart-seq2.
Picelli S
Nature Protocols, 9(1), 171-181 (2014)
Shangli Cheng et al.
Cell reports, 26(10), 2593-2607 (2019-03-07)
Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency, accompanied by dynamic changes in X chromosome activity in females. To investigate the molecular attributes of this process, we performed single-cell RNA-seq analysis of 1,724 cells of
Varsha Mathur et al.
Current biology : CB, 29(17), 2936-2941 (2019-08-20)
The apicomplexans are a group of obligate animal pathogens that include Plasmodium (malaria), Toxoplasma (toxoplasmosis), and Cryptosporidium (cryptosporidiosis) [1]. They are an extremely diverse and specious group but are nevertheless united by a distinctive suite of cytoskeletal and secretory structures related to
Stuart A S Craig
The American journal of clinical nutrition, 80(3), 539-549 (2004-08-24)
Betaine is distributed widely in animals, plants, and microorganisms, and rich dietary sources include seafood, especially marine invertebrates ( approximately 1%); wheat germ or bran ( approximately 1%); and spinach ( approximately 0.7%). The principal physiologic role of betaine is
Bernd C Schwahn et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17(3), 512-514 (2003-01-29)
Hyperhomocysteinemia, a proposed risk factor for cardiovascular disease, is also observed in other common disorders. The most frequent genetic cause of hyperhomocysteinemia is a mutated methylenetetrahydrofolate reductase (MTHFR), predominantly when folate status is impaired. MTHFR synthesizes a major methyl donor
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