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Key Documents

43388

Sigma-Aldrich

Esterase Isoenzyme 1 porcine liver, recombinant

recombinant, expressed in E. coli, ≥30.0 U/g

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About This Item

CAS Number:
Enzyme Commission number:
EC Number:
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in E. coli

form

crystalline
crystals
powder or flakes

specific activity

≥30.0 U/g

storage temp.

−20°C

Application

Esterase Isoenzymes may be used to identify the monocytic element in normal and leukemic cells. They may be used for the biochemical characterization of different hematopoietic cell lineages and stages of differentiation when studying leukemias and lymphomas. Esterase Isoenzyme 1, product 43388, is recombinant and from porcine liver. It is expressed in E. coli.

Biochem/physiol Actions

An esterase is a hydrolase that splits esters into acids and alcohols.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Unit Definition

1 U corresponds to the amount of enzyme which converts 1 μmol 4-nitrophenyl-L-acetate per minute at pH 7.5 and 30°C.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H G Drexler et al.
Cancer, 59(1), 77-82 (1987-01-01)
The expression of a particular alpha-naphthyl acetate esterase isoenzyme which is specific for monocytes was examined in a panel of cultured leukemia-lymphoma cell lines (n = 88), freshly obtained leukemia-lymphoma cells (n = 527), and in fresh (n = 10)
Esterase isoenzyme profiles of 255 leukemia-lymphoma cell lines from all hematopoietic cell lineages.
SM Gignac, ZB Hu, et al.
Leukemia Lymphoma, 22, 143-151 (1996)
Marie C Fortin et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(2), 326-331 (2012-12-12)
Studies on therapeutic drug disposition in humans have shown significant alterations as the result of pregnancy. However, it is not known whether pesticide metabolic capacity changes throughout pregnancy, which could affect exposure of the developing brain. We sought to determine
Joshua P Lewis et al.
Pharmacogenetics and genomics, 23(1), 1-8 (2012-11-01)
Carboxylesterase 1 (CES1) is the primary enzyme responsible for converting clopidogrel into biologically inactive carboxylic acid metabolites. We genotyped a functional variant in CES1, G143E, in participants of the Pharmacogenomics of Anti-Platelet Intervention (PAPI) study (n=566) and in 350 patients
Sascha Obrowsky et al.
Journal of lipid research, 54(2), 425-435 (2012-12-12)
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme mediating triglyceride (TG) hydrolysis. The lack of ATGL results in TG accumulation in multiple tissues, underscoring the critical role of ATGL in maintaining lipid homeostasis. Recent evidence suggests that ATGL affects TG

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