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5(6)-Carboxy-2′,7′-dichlorofluorescein

Name: 5(6)-Carboxy-2′,7′-dichlorofluorescein
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥95% (TLC)

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₀Cl₂O₇

CAS Number:

111843-78-8

Molecular Weight:

445.21

NACRES:

NA.32

PubChem Substance ID:

57647948

UNSPSC Code:

12352108

MDL number:

MFCD00037452

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Properties

product line

BioReagent

Quality Segment

100

assay

≥95% (TLC)

form

solid

solubility

DMF: soluble, DMSO: soluble, H₂O: soluble (pH ≥ 5)

fluorescence

λ_ex 504 nm; λ_em 529 nm in 0.1 M Tris pH 8.0

suitability

suitable for fluorescence

SMILES string

OC(=O)c1ccc(c(c1)C(O)=O)C2=C3C=C(Cl)C(=O)C=C3Oc4cc(O)c(Cl)cc24.OC(=O)c5ccc(C(O)=O)c(c5)C6=C7C=C(Cl)C(=O)C=C7Oc8cc(O)c(Cl)cc68

InChI

1S/2C21H10Cl2O7/c22-13-4-11-17(6-15(13)24)30-18-7-16(25)14(23)5-12(18)19(11)10-3-8(20(26)27)1-2-9(10)21(28)29;22-13-4-11-17(6-15(13)24)30-18-7-16(25)14(23)5-12(18)19(11)9-2-1-8(20(26)27)3-10(9)21(28)29/h2*1-7,24H,(H,26,27)(H,28,29)

InChI key

WHFHRELKGQJJBQ-UHFFFAOYSA-N

Description

Application

5(6)-Carboxy-2′,7′-dichlorofluorescein may be used as a specific substrate/probe to study the identity, activity and specificity of multidrug resistance protein 2 (MRP2) molecules.

suitable as pH-indicator

Other Notes

Fluorescent intracellular pH indicator in the pH 4-5 range[1]

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This Item	46935	70420	14562
Sigma-Aldrich 21882 5(6)-Carboxy-2′,7′-dichlorofluorescein	Sigma-Aldrich 46935 6-[Fluorescein-5(6)-carboxamido]hexanoic acid	Sigma-Aldrich 70420 Naphthofluorescein	Sigma-Aldrich 14562 2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein tetrakis(acetoxymethyl) ester
suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence
fluorescence λ_ex 504 nm; λ_em 529 nm in 0.1 M Tris pH 8.0	fluorescence λ_ex 491 nm; λ_em 515 nm in 0.1 M Tris pH 9.0	fluorescence λ_ex 594 nm; λ_em 663 nm in 0.1 M Tris pH 9.0	fluorescence λ_ex 482 nm; λ_em 528 nm in 0.1 M Tris pH 8.0 (esterase)
solubility DMF: soluble, H₂O: soluble (pH ≥ 5), DMSO: soluble	solubility DMF: soluble, DMSO: soluble	solubility DMF: soluble, DMSO: soluble, H₂O: soluble (pH ≥ 8)	solubility DMF: soluble, DMSO: soluble, acetonitrile: soluble
form solid	form solid	form powder	form solid
assay ≥95% (TLC)	assay ≥90% (HPCE)	assay -	assay -
product line BioReagent	product line -	product line -	product line BioReagent

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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