EZHPI

Human Proinsulin ELISA Kit

measures and quantifies Proinsulin levels in 20 μL serum or plasma

• Synonym(s): Human Proinsulin Detection, Proinsulin ELISA
• UNSPSC Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.32
• Input: sample type serum; sample type plasma (K2 EDTA)
• Assay range: accuracy: 88-103%, linearity: 84-120%, sensitivity: 0.5 pM, standard curve range: 2-200 pM
• Species reactivity: human
• Storage temp.: 2-8°C
• Shipped in: wet ice

Properties

• Product Name: Human Total Proinsulin ELISA, This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.
• Quality Segment: 200
• species reactivity: human
• packaging: kit of 1 × 96 wells
• parameter: 20 μL sample volume (4hr assay)
• assay range: accuracy: 88-103%, linearity: 84-120%, sensitivity: 0.5 pM, standard curve range: 2-200 pM
• technique(s): ELISA: suitable
• input: sample type serum; sample type plasma (K2 EDTA)
• NCBI accession no.: NM_000207.2
• UniProt accession no.: P01308
• application(s): research use
• detection method: colorimetric (450nm)
• shipped in: wet ice
• storage temp.: 2-8°C

Description

General description

Proinsulin, the precursor of insulin and C-peptide, is made by the β cells of the pancreas. Proinsulin formed by the cleavage of pre-proinsulin contains B- and A-domains linked through the connecting domain. Proinsulin interacts with insulin receptor-A (IR-A) isoform present in the nervous system and exhibits antiapoptotic and neuroprotective effects in the developing and postnatal nervous system. Elevated levels of proinsulin serve as a marker for secretory β-cell dysfunction. Increased levels of this hormone are also observed in patients with type 2 diabetes and impaired glucose tolerance. This kit measures the intact and intermediate metabolic forms of human proinsulin.

Application

Human Total Proinsulin ELISA has been used to measure plasma, serum, eye, and retinal levels of human proinsulin.

Other Notes

Research Sub Category
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature

Disclaimer

For research use only. Not for use in diagnostic procedures.

Safety Information

• pictograms: GHS05,GHS07
• signalword: Warning
• hcodes: H290,H317
• pcodes: P234 - P261 - P272 - P280 - P302 + P352 - P333 + P313
• Hazard Classifications: Met. Corr. 1 - Skin Sens. 1
• wgk: WGK 3
• Storage Class: 10 - Combustible liquids