Recommended Products
product line
NovaGel
Novabiochem®
Quality Level
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
2-8°C
General description
Aminomethyl NovaGel is a PEG-PS resin which has been designed to meet the requirements of organic chemists for resins of high substitution coupled with broad solvent compatibility. This support has a nominal loading of 0.7 mmole/g – almost twice that of comparable resins – but still retains most of the swelling characteristics of conventional PEG-PS supports. It is prepared from a special high-swell version of AM resin by partial derivatization with methyl-PEG-p-nitrophenylcarbonate [1]. Resin functionality is provided by residual aminomethyl groups. The urethane linkage between the PEG and the base resin is stable to strongly acidic, basic and reducing conditions, ensuring minimal loss of PEG chains during synthesis. Furthermore, because the linker is not attached to the end of the PEG chains, if leaching of PEG does occur, the product is not contaminated with U.V. absorbing linker-PEG fragments which can complicate the nmr spectra and HPLC profiles of products obtained with other PEG-PS supports.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] J. H. Adams, et al. (1998) J. Org. Chem., 63, 3706.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] J. H. Adams, et al. (1998) J. Org. Chem., 63, 3706.
Linkage
Replaces: 01-64-0283
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 0.90 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
The PEG-PS resin is prepared from aminomethyl copoly (Styrene 1% DVB), 100 - 200 mesh.
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 0.90 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
The PEG-PS resin is prepared from aminomethyl copoly (Styrene 1% DVB), 100 - 200 mesh.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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