8.53030

Boc-Asp(OcHx)-OH

Novabiochem^®

• Synonym(s): Boc-Asp(OcHx)-OH, N-α-t.-Boc-L-aspartic acid β-cyclohexyl ester
• Empirical Formula (Hill Notation): C₁₅H₂₅NO₆
• CAS Number: 73821-95-1
• Molecular Weight: 315.36
• MDL number: MFCD00061996
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥98% (TLC)
• form: powder
• reaction suitability: reaction type: Boc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 93-95 °C
• application(s): peptide synthesis
• functional group: carboxylic acid
• storage temp.: 2-30°C
• InChI: 1S/C15H25NO6/c1-15(2,3)22-14(20)16-11(13(18)19)9-12(17)21-10-7-5-4-6-8-10/h10-11H,4-9H2,1-3H3,(H,16,20)(H,18,19)/t11-/m0/s1
• InChI key: NLPQIWFEEKQBBN-NSHDSACASA-N

Description

General description

Standard building block for introduction of aspartic acid in Boc SPPS. Minimizes aspartimide formation, particularly in problematic sequences such as Asp-Gly ^[1,2,3].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Literature references

^[1] J. P. Tam, et al. (1979) Tetrahedron Lett., 42, 4033.
^[2] E. Nicolas, et al. (1989) Tetrahedron Lett., 30, 497.
^[3] B. Penke, et al. in ′Peptides 1988, Proc. 20th European Peptide Symposium′, G. Jung & E. Bayer (Eds), Walter de Gruyter, Berlin, 1989, pp. 67.

Linkage

Replaces: 04-12-0123

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=2 in AcOH): +5.0 - +7.0 °
Purity (TLC(157A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable