8.51028

Bis-Boc-amino-oxyacetic acid

Novabiochem^®

• Synonym(s): Bis-Boc-amino-oxyacetic acid, Boc ₂-Aoa-OH
• Empirical Formula (Hill Notation): C₁₂H₂₁NO₇ · xH₂O
• Molecular Weight: 291.30 (anhydrous basis)
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥97% (TLC)
• form: powder
• reaction suitability: reagent type: ligand
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• storage temp.: 2-8°C

Description

General description

This reagent can be used to introduce a hydroxylamine functionality to N-terminal or side-chain amino groups. Hydroxylamine-labeled peptides prepared in this manner can be ligated in aqueous solution at pH 3.5 to aldehyde-containing peptides via oxime formation. This bis-protected derivative eliminates oligomer formation which can occur with mono-protected hydroxylamine reagents as a result of double acylation. Coupling of this derivative should be done using an OSu ester.

Literature references

^[1] J. C. Spetzler & T. Hoeg-Jensen (2001) J. Peptide Sci., 7, 537.

Linkage

Replaces: 01-63-0129

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 97 %
Water (K. F.): 3.0 - 8.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3