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565780

Sigma-Aldrich

β-Secretase Inhibitor III

The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym(s):

β-Secretase Inhibitor III, Inhibitor GL189, H-EVNstatineVAEF-NH₂

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About This Item

Empirical Formula (Hill Notation):
C44H70N10O14
Molecular Weight:
963.09
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

DMSO: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.
A substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells.

Biochem/physiol Actions

Cell permeable: no
Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells
Primary Target
BACE
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Capell, A., et al. 2002. J. Biol. Chem.277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem.45, 259.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inmaculada Lopez-Font et al.
Molecular neurobiology, 56(12), 8603-8616 (2019-07-11)
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the main brain β-secretase responsible for the amyloidogenic processing of the amyloid precursor protein (APP). Previous studies have suggested that cerebrospinal fluid (CSF) β-secretase activity may be a candidate diagnostic

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