5.08510

ZD 7288

• Synonym(s): ZD 7288, 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyrimidiniumchloride, Zeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
• Empirical Formula (Hill Notation): C₁₅H₂₁ClN₄
• CAS Number: 133059-99-1
• Molecular Weight: 292.81
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
• InChI key: DUWKUHWHTPRMAP-UHFFFAOYSA-N

Description

General description

ZD7288 is a potent HCN blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na⁺ currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.

Biochem/physiol Actions

Primary Target
HCN channel

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pleasenote that the molecular weight for this compound is batch-specific due tovariable water content.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable