420139

JAK2 Inhibitor IV

The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): JAK2 Inhibitor IV, 3-Amino-5-(N- tert-butylsulfonamido-4-phenyl)-indazole
• Empirical Formula (Hill Notation): C₁₇H₂₀N₄O₂S
• CAS Number: 1110502-30-1
• Molecular Weight: 344.43
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: pale yellow
• solubility: ethanol: 3 mg/mL; DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20)
• InChI key: KFJCXIOVAGJCKB-UHFFFAOYSA-N

Description

General description

An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC₅₀ = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC₅₀ = 2.93 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett.19, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable