205531
CA-074 Me
≥98% (HPLC), solid, Cathepsin B inhibitor, Calbiochem®
Synonym(s):
CA-074 Me, Cathepsin B Inhibitor IV, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
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About This Item
Empirical Formula (Hill Notation):
C19H31N3O6
Molecular Weight:
397.47
UNSPSC Code:
12352200
NACRES:
NA.77
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product name
CA-074 Me, CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
Quality Level
Assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cathepsin B
cathepsin B
Product does not compete with ATP.
Reversible: no
Target IC50: 2.24 nM against cathepsin B
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sever, N., et al. 2002. Biol. Chem.383, 839.
Authier, F., et al. 1999. J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Authier, F., et al. 1999. J. Biol. Chem.274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Carolina Duarte et al.
Journal of cellular and molecular medicine, 26(10), 2841-2851 (2022-04-17)
Emerging studies indicate that intracellular eukaryotic ceramide species directly activate cathepsin B (CatB), a lysosomal-cysteine-protease, in the cytoplasm of osteoclast precursors (OCPs) leading to elevated RANKL-mediated osteoclastogenesis and inflammatory osteolysis. However, the possible impact of CatB on osteoclastogenesis elevated by
Michael C Yoon et al.
Biochemistry, 61(4), 228-238 (2022-02-05)
CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human disease mechanisms involves its
Katia Fettucciari et al.
Cellular and molecular life sciences : CMLS, 79(8), 442-442 (2022-07-22)
Clostridioides difficile infection (CDI) causes nosocomial/antibiotic-associated gastrointestinal diseases with dramatically increasing global incidence and mortality rates. The main C. difficile virulence factors, toxins A and B (TcdA/TcdB), cause cytopathic/cytotoxic effects and inflammation. We demonstrated that TcdB induces caspase-dependent, mitochondria-independent enteric
Qi Feng Lin et al.
Journal of virology, 97(10), e0082823-e0082823 (2023-09-25)
Reoviruses infect many mammals and are widely studied as a model system for enteric viruses. However, most of our reovirus knowledge comes from laboratory strains maintained on immortalized L929 cells. Herein, we asked whether naturally circulating reoviruses possess the same
Soo-Jin Oh et al.
Cell death discovery, 9(1), 100-100 (2023-03-23)
While the mechanism of lipotoxicity by palmitic acid (PA), an effector of metabolic stress in vitro and in vivo, has been extensively investigated, molecular details of lipotoxicity are still not fully characterized. Since recent studies reported that PA can exert
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