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860560C

Avanti

18:1-12:0 Biotin PS

Avanti Research - A Croda Brand 860560C

Synonym(s):

1-oleoyl-2-(12-biotinyl(aminododecanoyl))-sn-glycero-3-phospho-L-serine (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C46H86N5O12PS
CAS Number:
Molecular Weight:
964.24
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (860560C-1mg)

manufacturer/tradename

Avanti Research - A Croda Brand 860560C

concentration

1 mg/mL (860560C-1mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCCNC(CCCC[C@]1([H])SC[C@@]2([H])[C@]1([H])NC(N2)=O)=O)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

InChI

1S/C46H83N4O12PS.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-14-17-20-23-30-42(52)59-33-37(34-60-63(57,58)61-35-38(47)45(54)55)62-43(53)31-24-21-18-15-13-16-19-22-27-32-48-41(51)29-26-25-28-40-44-39(36-64-40)49-46(56)50-44;/h9-10,37-40,44H,2-8,11-36,47H2,1H3,(H,48,51)(H,54,55)(H,57,58)(H2,49,50,56);1H3/b10-9-;/t37-,38+,39+,40+,44+;/m1./s1

InChI key

FUCJSUOHIUUCPS-FNICJJOFSA-N

General description

18:1-12:0 Biotin PS is a biotinylated lipid.

Application

18:1-12:0 Biotin PS may be used in lipid blot analysis to study Niemann-Pick C2 (NPC2)-lipid interactions.

Packaging

5 mL Clear Glass Sealed Ampule (860560C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3


Certificates of Analysis (COA)

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Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
McCauliff LA, et al.
eLife, 8 (2019)
Peter A Leventis et al.
Annual review of biophysics, 39, 407-427 (2010-03-03)
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly

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