860474P
Avanti
1-deoxysphinganine-d3
Avanti Research™ - A Croda Brand 860474P, powder
Synonym(s):
1-deoxysphinganine-d3 (m18:0)
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About This Item
Empirical Formula (Hill Notation):
C18H36D3NO
CAS Number:
Molecular Weight:
288.53
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 500 μg (860474P-500ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860474P
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCCCC[C@](O)([H])[C@](N)([H])C([2H])([2H])[2H]
General description
1-deoxysphinganine-d3 is a deuterated compound, wherein the three protons of deoxysphinganine are replaced by deuterium. 1-deoxysphinganine is an atypical sphingoid base devoid of a 1-hydroxyl group.
Biochem/physiol Actions
1-deoxysphinganine acts as a biomarker for Type 2 diabetes. It can function as a cytotoxic lipid for insulin producing cells. 1-deoxysphinganine might exhibit toxicity to cancerous cells.
Packaging
5 mL Amber Glass Screw Cap Vial (860474P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells.
Richard A Zuellig et al.
Diabetes, 63(4), 1326-1339 (2014-01-01)
Irreversible failure of pancreatic β-cells is the main culprit in the pathophysiology of diabetes, a disease that is now a global epidemic. Recently, elevated plasma levels of deoxysphingolipids, including 1-deoxysphinganine, have been identified as a novel biomarker for the disease.
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that
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