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About This Item
Empirical Formula (Hill Notation):
C23H28N2O11
Molecular Weight:
508.48
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
>90%
form
solid or viscous liquid
reaction suitability
reactivity: amine reactive
reagent type: cross-linking reagent
reactivity: thiol reactive
functional group
NHS ester
polymer architecture
shape: linear
functionality: heterobifunctional
shipped in
ambient
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O
Features and Benefits
Phthalimidooxy-dPEG®4-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.
Legal Information
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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