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F6206

Sigma-Aldrich

4-Fluorobenzenesulfonyl chloride

98%

Synonym(s):

4-Fluorobenzene-1-sulfonyl chloride, p-Fluorobenzenesulfonyl chloride

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About This Item

Linear Formula:
FC6H4SO2Cl
CAS Number:
349-88-2
Molecular Weight:
194.61
Beilstein:
2091633
EC Number:
206-493-0
MDL number:
MFCD00007438
UNSPSC Code:
12352100
PubChem Substance ID:
24894904
NACRES:
NA.22

Assay

98%

bp

95-96 °C/2 mmHg (lit.)

mp

29-31 °C (lit.)

SMILES string

Fc1ccc(cc1)S(Cl)(=O)=O

InChI

1S/C6H4ClFO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H

InChI key

BFXHJFKKRGVUMU-UHFFFAOYSA-N

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Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Y A Chang et al.
Bioconjugate chemistry, 3(2), 200-202 (1992-03-01)
4-Fluorobenzenesulfonyl chloride (fosyl chloride), due to the strong electron-withdrawing property of its fluoride atom, is found to be an excellent activating agent for the covalent attachment of biologicals to a variety of solid supports (e.g. functionalized polystyrene microspheres, Sepharose beads
T H Liao et al.
Analytical biochemistry, 148(2), 365-375 (1985-08-01)
The reagent p-fluorobenzenesulfonyl chloride modifies the protein side chains of tyrosine, lysine, and histidine and the alpha-NH2 group. The p-fluorobenzenesulfonyl (Fbs-) group, identified by the 19F nuclear magnetic resonance signal, exhibits a different 19F chemical shift for each functional group
Umaprasana Ojha et al.
Langmuir : the ACS journal of surfaces and colloids, 25(11), 6319-6327 (2009-04-02)
Peptide surface modification of poly[(methyl methacrylate-co-hydroxyethyl methacrylate)-b-isobutylene-b-(methyl methacrylate-co-hydroxyethyl methacrylate)] P(MMA-co-HEMA)-b-PIB-b-P(MMA-co-HEMA) triblock copolymers with different HEMA/MMA ratios has been accomplished using an efficient synthetic procedure. The triblock copolymers were reacted with 4-fluorobenzenesulfonyl chloride (fosyl chloride) in pyridine to obtain the activated
Ning Li et al.
European journal of medicinal chemistry, 155, 531-544 (2018-06-18)
Ten novel symmetric 3,5-bis(arylidene)-4-piperidone derivatives (BAPs, 1-10) and fourteen dissymmetric BAPs (11-24) were synthesized and evaluated the cytotoxicity. All of the compounds have been screened for their anti-inflammatory activity characterized by evaluating their inhibitory effects on LPS-induced IL-6, TNF-α secretion.
Abdelaziz Houmam et al.
Physical chemistry chemical physics : PCCP, 14(1), 113-124 (2011-09-15)
Important aspects of the electrochemical reduction of a series of substituted arene sulfonyl chlorides are investigated. An interesting autocatalytic mechanism is encountered where the starting material is reduced both at the electrode and through homogeneous electron transfer from the resulting

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