901397

Poly(ethylene glycol) linear dendrimer

NHBoc terminated, PEG M_n 6000, generation 4

• Synonym(s): Dendron bifunctionalized PEG, PFD-G4-PEG6k-NHBoc, Polyethylene glycol
• Empirical Formula (Hill Notation): C₆₇₈H₁₂₀₂N₃₂O₃₂₃
• Molecular Weight: 14970.82
• UNSPSC Code: 51171641
• NACRES: NA.23

Properties

• Quality Level: 100
• form: solid
• mol wt: PEG M_n 6000
• color: white to off-white
• storage temp.: −20°C

Description

General description

• Polymer architecture: Dendron-functionalized PEG
• Generation: 4
• PEG Average Mn: 6,000
• End group functionality: Boc-protected amine
• No. surface groups: 32
• Calculated mol. wt.: 14970.98 g/mol
• Boc: tert-Butyloxycarbonyl
• Bis-MPA: 2,2-bis(hydroxymethyl)propionic acid

Application

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. PEG-core dendrimers feature excellent solubility in water and a high degree of functionality per PEG chain, making them strong candidates for advanced drug delivery systems or as targeting vessels. Additionally, the terminal amine groups can readily be used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds, to yield highly functionalized materials for a variety of biomedical applications.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable