80631

Sodium bis(trimethylsilyl)amide solution

40% in THF

• Synonym(s): HMN-Na Sol, NaHMDS solution, Hexamethyldisilazane sodium salt solution
• Linear Formula: [(CH₃)₃Si]₂NNa
• CAS Number: 1070-89-9
• Molecular Weight: 183.37
• Beilstein: 3629917
• MDL number: MFCD00009835
• UNSPSC Code: 12352111
• PubChem Substance ID: 57652836
• NACRES: NA.22

Properties

• form: liquid
• Quality Level: 200
• concentration: 40% in THF
• SMILES string: C[Si](C)(C)N([Na])[Si](C)(C)C
• InChI: 1S/C6H18NSi2.Na/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
• InChI key: WRIKHQLVHPKCJU-UHFFFAOYSA-N

Description

Application

• Sodium bis(trimethylsilyl)amide, also known as NaHMDS, is a metal dialkylamide reagent that combines both high basicity and nucleophilicity. It is a general reagent used for the enolization of carbonyl compounds.
• It can be used to prepare phosphonium ylides in Wittig reaction.
• NaHMDS solution can also be used as a source of nitrogen in aminomethylation and in the synthesis of primary amines from the corresponding alkyl halides.

Other Notes

prices for bulk quantities on request

Safety Information

• Pictograms: GHS02,GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H314,H335,H336,H351
• Precautionary Statements: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH014,EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 1.4 °F - closed cup
• Flash Point(C): -17 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves