302759

Benzylmagnesium chloride solution

1.0 M in diethyl ether

• Synonym(s): (Phenylmethyl)magnesium chloride, Benzylchloromagnesium, Chloro(phenylmethyl)magnesium
• Linear Formula: C₆H₅CH₂MgCl
• CAS Number: 6921-34-2
• Molecular Weight: 150.89
• Beilstein: 878506
• MDL number: MFCD00000469
• UNSPSC Code: 12352103
• PubChem Substance ID: 24858271
• NACRES: NA.22

Properties

• reaction suitability: reaction type: Grignard Reaction
• concentration: 1.0 M in diethyl ether
• density: 0.794 g/mL at 25 °C
• SMILES string: Cl[Mg]Cc1ccccc1
• InChI: 1S/C7H7.ClH.Mg/c1-7-5-3-2-4-6-7;;/h2-6H,1H2;1H;/q;;+1/p-1
• InChI key: NRAFPLGJPPJUNB-UHFFFAOYSA-M

Description

General description

Benzylmagnesium chloride is a versatile Grignard reagent frequently used in organic synthesis. It can be used as a reagent in the addition reaction with carbonyl compounds, nitriles, epoxides, and alkyl halides to synthesize various alcohols, amines, and ketones. Additionally, it is also used in reductions, cross-coupling, allylation and alkylation reactions.

Application

Benzylmagnesium chloride solution (1.0 M in diethyl ether) is used as a reagent to provide the benzyl group required for the synthesis of the desired sulfonic acid-functionalized alkoxysilane. It is also used in the anionic polymerization of styrene to form styrenyl magnesium chloride, which is further used as an initiator in the synthesis of polyolefin-block-polystyrene block copolymers.

Safety Information

• Pictograms: GHS02,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302,H314,H336
• Precautionary Statements: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Target Organs: Central nervous system
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): -40.0 °F - closed cup
• Flash Point(C): -40 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves