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Sigma-Aldrich

2,2,2-Trifluoroethylamine hydrochloride

98%

Synonym(s):

2-Amino-1,1,1-trifluoroethane hydrochloride

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About This Item

Linear Formula:
CF3CH2NH2 · HCl
CAS Number:
373-88-6
Molecular Weight:
135.52
Beilstein:
3652103
EC Number:
206-771-1
MDL number:
MFCD00012875
UNSPSC Code:
12352100
PubChem Substance ID:
24850866
NACRES:
NA.22

Quality Level

100

Assay

98%

mp

220-222 °C (subl.) (lit.)

SMILES string

Cl.NCC(F)(F)F

InChI

1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H

InChI key

ZTUJDPKOHPKRMO-UHFFFAOYSA-N

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Application

2,2,2-Trifluoroethylamine hydrochloride was used in the derivatization of aqueous carboxylic acids to the corresponding 2,2,2-trifluoroethylamide derivative.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Quincy LaRon Ford et al.
Journal of chromatography. A, 1145(1-2), 241-245 (2007-02-20)
We report a technique for the rapid, room temperature derivatization of aqueous carboxylic acids to the corresponding 2,2,2-trifluoroethylamide derivative. 3-Ethyl-1-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDC) and 2,2,2-trifluoroethylamine hydrochloride (TFEA) were added to aqueous samples of several acids of interest in environmental analytical chemistry
Yoshikazu Hattori et al.
Journal of biomolecular NMR, 68(4), 271-279 (2017-08-02)
The preparation of stable isotope-labeled proteins is important for NMR studies, however, it is often hampered in the case of eukaryotic proteins which are not readily expressed in Escherichia coli. Such proteins are often conveniently investigated following post-expression chemical isotope

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