跳转至内容
Merck
  • Early exercise induces long-lasting morphological changes in cortical and hippocampal neurons throughout of a sedentary period of rats.

Early exercise induces long-lasting morphological changes in cortical and hippocampal neurons throughout of a sedentary period of rats.

Scientific reports (2019-09-25)
Fernando Tadeu Serra, Andrea Dominguez Carvalho, Bruno Henrique Silva Araujo, Laila Brito Torres, Fabrizio Dos Santos Cardoso, Jéssica Salles Henrique, Eduardo Varejão Díaz Placencia, Roberto Lent, Fernando Gomez-Pinilla, Ricardo Mario Arida, Sérgio Gomes da Silva
摘要

Life experiences at early ages, such as physical activity in childhood and adolescence, can result in long-lasting brain effects able to reduce future risk of brain disorders and to enhance lifelong brain functions. However, how early physical exercise promotes these effects remains unclear. A possible hypothesis is that physical exercise increases the expression of neurotrophic factors and stimulates neuronal growth, resulting in a neural reserve to be used at later ages. Basing our study on this hypothesis, we evaluated the absolute number and morphology of neuronal cells, as well as the expression of growth, proliferation and survival proteins (BDNF, Akt, mTOR, p70S6K, ERK and CREB) in the cerebral cortex and hippocampal formation throughout of a sedentary period of rats who were physically active during youth. To do this, male Wistar rats were submitted to an aerobic exercise protocol from the 21st to the 60th postnatal days (P21-P60), and evaluated at 0 (P60), 30 (P90) and 60 (P120) days after the last exercise session. Results showed that juvenile exercise increased, and maintained elevated, the number of cortical and hippocampal neuronal cells and dendritic arborization, when evaluated at the above post-exercise ages. Hippocampal BDNF levels and cortical mTOR expression were found to be increased at P60, but were restored to control levels at P90 and P120. Overall, these findings indicate that, despite the short-term effects on growth and survival proteins, early exercise induces long-lasting morphological changes in cortical and hippocampal neurons even during a sedentary period of rats.

材料
货号
品牌
产品描述

Millipore
MILLIPLEX® 大鼠垂体磁珠面板-内分泌多重检测, The analytes available for this multiplex kit are: ACTH, BDNF, FSH, GH, LH, Prolactin, TSH.
Millipore
MILLIPLEX® 大鼠应激激素磁珠面板-内分泌多重检测, This MILLIPLEX MAP Rat Stress Hormone Magnetic Bead Panel is an Endocrine multiplex assay. The analytes available for this multiplex kit are: ACTH, Corticosterone, Melatonin.