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UC305

Sigma-Aldrich

O-Desmethylnaproxen

别名:

(S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid, d-2-(6-Hydroxy-2-naphthyl)proprionic acid

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About This Item

经验公式（希尔记法）:
C13H12O3
CAS号:
52079-10-4
分子量:
216.23
Beilstein:
8838512
MDL號碼:
MFCD00869765
分類程式碼代碼:
12161501
PubChem物質ID:
329827666
NACRES:
NA.77

形狀

solid

品質等級

200

顏色

white

mp

182-183 °C

儲存溫度

2-8°C

SMILES 字串

C[C@H](C(O)=O)c1ccc2cc(O)ccc2c1

InChI

1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1

InChI 密鑰

XWJUDDGELKXYNO-QMMMGPOBSA-N

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應用

O-Desmethylnaproxen can be used for assaying naproxen metabolites.

生化／生理作用

CYP2C9 metabolite of naproxen

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

象形圖

Exclamation markEnvironment
GHS07,GHS09

訊號詞

Warning

危險聲明

H302,H317,H400

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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T B Vree et al.
Journal of chromatography, 578(2), 239-249 (1992-07-24)
Naproxen is metabolized in humans by O-demethylation, and by acyl glucuronidation to the 1-O-glucuronide. Naproxen, its metabolite and the conjugates can be measured directly by gradient high-performance liquid chromatographic analysis without enzymic deglucuronidation. The glucuronide conjugates were isolated by preparative
Amitava Dasgupta et al.
American journal of clinical pathology, 133(6), 878-883 (2010-05-18)
A recent report indicated significant interference of naproxen with total bilirubin measurement when using the Jendrassik and Grof method. We explored the possibility of avoiding this interference by using a different method. We observed that naproxen has no effect on
High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.
C H Kiang et al.
Journal of chromatography, 383(2), 449-455 (1986-12-19)
P J Guelen et al.
International journal of clinical pharmacology, therapy, and toxicology, 26(4), 190-193 (1988-04-01)
After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.6 h. Ten out of 22 subjects show biphasic elimination kinetics
Hypoalbuminaemia and naproxen pharmacokinetics in a patient with rheumatoid arthritis.
F A Van den Ouweland et al.
Clinical pharmacokinetics, 11(6), 511-515 (1986-11-01)
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