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生物源
human
重組細胞
expressed in HEK 293 cells
籤條
6-His tagged (C-terminus)
化驗
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
calculated mol wt 30 kDa
observed mol wt 30 kDa (DTT-reduced. Ser 2 is the predicted N-terminal .)
包裝
pkg of 10 μg
pkg of 50 μg
雜質
<1 EU/μg endotoxin (LAL test)
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... CA2(760)
一般說明
Carbonic Anhydrase 2 (CA2) is a zinc metalloenzyme and it helps in regulating acid-base balance in cells. It is a ubiquitous cytosolic protein. Carbonic anhydrase 2 also known as carbonate dehydratase II, carbonic anhydrase C, belongs to the class of a carbonic anhydrases. The associated gene is mapped to human chromosome 8q21.
應用
Carbonic Anhydrase 2/CA2 human has been used for CA2 ELISA (enzyme-linked immunosorbent assay).
生化／生理作用
Carbonic Anhydrase 2 (CA2) catalyzes the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa). CA2 can bind to various transporters, such as anion exchanger 1 (AE1), NBCe1 (Na(+)/HCO3(-) cotransporter), NHE3 (Na(+)/H(+) exchanger 3) and MCT (monocarboxylate transporter). This association increases the rate of transport. Mutations in the CA2 gene are responsible for carbonic anhydrase II (CAII) deficiency syndrome, an autosomal recessive osteopetrosis characterised with renal tubular acidosis as well as cerebral calcifications. Changes in the expression of CA2 are linked with carcinogenesis.
外觀
Lyophilized from 0.22 μm filtered solution in 20 mM Tris, pH 8.0, with 150 mM NaCl, 1 mM DTT. Normally Mannitol or Trehalose is added as protectants before lyophilization.
重構
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A study of anti-carbonic anhydrase II antibodies in rheumatic autoimmune diseases.
Ono M, et al.
Journal of Dermatological Science, 21, 183-183 (1999)
Two novel CAII mutations causing carbonic anhydrase II deficiency syndrome in two unrelated Chinese families.
Pang Q, et al.
Metabolic Brain Disease, 30, 989-989 (2005)
Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei.
Jarvinen P, et al.
Acta Pathologica, Microbiologica et Immunological Scandinavica, 125, 207-207 (2017)
Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3.
Krishnan D, et al.
American Journal of Physiology: Renal Physiology, 309, F383-F383 (2015)
Metabolon disruption: a mechanism that regulates bicarbonate transport.
Alvarez BV, et al.
The Embo Journal, 24, 2499-2499 (2005)
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