SRP0699

STK9 Protein

recombinant

• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 重組細胞: expressed in baculovirus infected Sf9 cells
• 化驗: 70-95% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~84 kDa
• 濃度: 0.1 μg/μL
• 登錄號: NM_003159
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... STK9(6792)

说明

應用

Useful for Western blot.

生化／生理作用

Recombinant human STK9 (CDKL5) (1-498) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. STK9 or CDKL5 is a member of Ser/Thr protein kinase family which has protein kinase activity and is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). STK9 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing, by controlling splicing factor dynamics ⁽¹⁾. The mutations in the STK9 is a major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder ⁽²⁾.

重構

Formulated in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

儲存和穩定性

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable