SML3663
CAY10499
≥98% (HPLC)
别名:
Benzyl 4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenylcarbamate, CAY 10499, CAY-10499, LEI 103, LEI-103, LEI103, Phenylmethyl N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]carbamate, [4-(5-Methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-carbamic acid phenylmethyl ester
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About This Item
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生化/生理作用
CAY10499 is a potent inhibitor against fatty acid amide hydrolase, hormone-sensitive lipase, and monoglyceride lipase (FAAH/HSL/MGL(MAGL) IC50 = 86/90/92 nM). Note: CAY10499 is reported to be irreversible by Muccioli et al. (PMID 18855964) and reversible by Minkkila et al. (PMID 19472270). Reported IC50 values vary depending greatly on pre-incubation time, substrates, enzyme source, as well as other experimental parameters employed.
Potent inhibitor against fatty acid amide hydrolase (FAAH), hormone-sensitive lipase (HSL), and monoglyceride lipase (MAGL, MGL).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Orly Laufman et al.
Cell, 178(2), 275-289 (2019-06-18)
Positive-stranded RNA viruses extensively remodel host cell architecture to enable viral replication. Here, we examined the poorly understood formation of specialized membrane compartments that are critical sites for the synthesis of the viral genome. We show that the replication compartments
Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.
Anna Minkkilä et al.
ChemMedChem, 4(8), 1253-1259 (2009-05-28)
Giulio G Muccioli et al.
Chembiochem : a European journal of chemical biology, 9(16), 2704-2710 (2008-10-16)
Monoglyceride lipase (MGL) plays a major role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). This endocannabinoid is known to mediate a large number of physiological processes, and its regulation is thought to be of great therapeutic potential. However
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