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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear (Wramed)
儲存溫度
2-8°C
InChI
1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
InChI 密鑰
WKSAUQYGYAYLPV-UHFFFAOYSA-N
生化／生理作用
Pyrimethamine is an antiparasitic drug used to treat malaria, toxoplasmosis and cystoisosporiasis. Pyrimethamine is a potent inhibitor of dihydrofolate reductase.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
The multifaceted antineoplastic role of pyrimethamine against human malignancies
Shanaya Ramchandani
IUBMB Life, 74, 198-212 (2022)
Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance
C V Plowe
The Journal of Infectious Diseases, 176, 1590-1596 (1997)
Lisa N Heppler et al.
The Journal of biological chemistry, 298(2), 101531-101531 (2021-12-27)
Cancer is often characterized by aberrant gene expression patterns caused by the inappropriate activation of transcription factors. Signal transducer and activator of transcription 3 (STAT3) is a key transcriptional regulator of many protumorigenic processes and is persistently activated in many
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