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品質等級
化驗
≥98% (HPLC)
形狀
oil
顏色
colorless to yellow
儲存溫度
−20°C
InChI
1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1
InChI 密鑰
YCYMCMYLORLIJX-SNVBAGLBSA-N
生化／生理作用
ONO-2506 (arundic acid; (R)-2-propyloctanoic acid) is an inhibitory astrocytes-modulating agent that exerts glioprotective effects against amyloid-β-peptide (Aβ)-induced glial death in astrocyte cultures (50 μM ONO-2506 against 200 μM Aβ25-35, 24 hr; 1321N1 astrocytes) by decreasing both the intracellular and extracellular S100B levels. Blockade of astrocytic activation by ONO-2506 in vivo is shown to offer therapeutic efficacy in animal models of normal tension glaucoma (10 mg/kg po. mice), spinal cord injury (20 mg/kg/d ip or iv rats), brain seizure, ischemic stroke (10 mg/kg/d ip or iv rats), and Parkinson′s disease (30 mg/kg ip mice).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Mojtaba Keshavarz et al.
Iranian journal of basic medical sciences, 22(5), 557-562 (2019-06-21)
Valproic and arundic acids are astrocytes-modulating agents with potential effects in the treatment of Alzheimer's disease (AD). S100B is an astrocytic cytokine with a possible role in the pathogenesis of AD. In this study, we aimed to assess the glioprotective
Mitsuru Hanada et al.
Journal of the neurological sciences, 337(1-2), 186-192 (2013-12-24)
Arundic acid (ONO-2506) inhibits the production and release of S100 protein from astrocytes. While numerous studies have assessed the effect of ONO-2506 in the diseased brain, to the best of our knowledge, no study has examined the effect of ONO-2506
Isato Fukushi et al.
Respiratory physiology & neurobiology, 226, 24-29 (2015-11-26)
Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles
Narito Tateishi et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 22(6), 723-734 (2002-06-05)
A novel agent, (R)-(-)-2-propyloctanoic acid (ONO-2506), has a unique property in that it modulates functions of activated cultured astrocytes, including pronounced inhibition of S-100beta synthesis. The present study examined whether administration of this agent would mitigate the delayed expansion of
C Mari et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 76, 41-51 (2019-06-17)
Perinatal hypoxia-ischemia (HI) is one of the main causes of mortality and chronic neurological morbidity in infants and children. Astrocytes play a key role in HI progression, becoming reactive in response to the injury, releasing S100 calcium binding protein B
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