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SML2870

Sigma-Aldrich

BI 99179

≥98% (HPLC)

别名:

(1R,3S)-3-Propionylaminocyclopentanecarboxylic acid N-[4-(benzoxazol-2-yl)phenyl]-N-methylamide, (1R,3S)-N-[4-(2-Benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]cyclopentanecarboxamide, BI99179

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About This Item

经验公式（希尔记法）:
C23H25N3O3
CAS号:
1291779-76-4
分子量:
391.46
MDL號碼:
MFCD25976795
分類程式碼代碼:
51111800
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

CCC(N[C@H]1CC[C@@H](C(N(C)C2=CC=C(C=C2)C3=NC4=C(O3)C=CC=C4)=O)C1)=O

生化／生理作用

BI 99179 is a non-cytotoxic (by LDH release; 30 μM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20% inhibition at 10 μM) and human CYP450 isoenzymes (1A2/2C9/2C19/2D6/3A4 IC50 >10 μM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg).

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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Jörg T Kley et al.
Bioorganic & medicinal chemistry letters, 21(19), 5924-5927 (2011-08-30)
Based on a high-throughput screen, cyclopentanecarboxanilides were identified as a new chemotype of non-covalent inhibitors of type I fatty acid synthase (FAS). Starting from initial hits we aimed at generating a tool compound suitable for the in vivo validation of

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