SML2579

Tafluprost acid

≥98% (HPLC)

• 别名: (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-Heptenoic acid, 9α,11α-dihydroxy-15,15-difluoro-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, AFP-172
• 经验公式（希尔记法）: C₂₂H₂₈F₂O₅
• CAS号: 209860-88-8
• 分子量: 410.45
• MDL號碼: MFCD08062149
• 分類程式碼代碼: 12352106
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: oil
• 光學活性: [α]/D 17 to 22°, c = 1.0 in methanol
• 顏色: colorless
• 儲存溫度: −20°C
• InChI: 1S/C22H28F2O5/c23-22(24,15-29-16-8-4-3-5-9-16)13-12-18-17(19(25)14-20(18)26)10-6-1-2-7-11-21(27)28/h1,3-6,8-9,12-13,17-20,25-26H,2,7,10-11,14-15H2,(H,27,28)/b6-1-,13-12+/t17-,18-,19+,20-/m1/s1
• InChI 密鑰: KIQXRQVVYTYYAZ-VKVYFNERSA-N

说明

生化／生理作用

Taflupost acid is the active metabolite of Tafluprost, a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. Taflupost acid has high affinity and selectivity for the prostaglandin PGF2α (FP) receptor with a Ki of 0.4 nM.

安全信息

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361d
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable