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Merck
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文件

SML2259

Sigma-Aldrich

拉帕替尼

≥98% (HPLC)

别名:

拉帕替尼, GD 2016, GSK 572016, GW-572016, GW572016, N-（3-氯-4-（（3-氟苯基）甲氧基）苯基）-6-（5-（（2-甲基磺酰基乙基氨基）甲基）-2-呋喃基）喹唑啉-4-胺, N-（3-氯-4-（（3-氟苯基）甲氧基）苯基）-6-（5-（（（（2-（甲基磺酰基）乙基）氨基）甲基）-2-呋喃基）-4-喹唑啉胺

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About This Item

经验公式（希尔记法）:
C29H26ClFN4O4S
CAS号:
231277-92-2
分子量:
581.06
MDL號碼:
MFCD09264194
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CS(=O)(CCNCC1=CC=C(C2=CC=C3N=CN=C(C3=C2)NC4=CC=C(C(Cl)=C4)OCC5=CC=CC(F)=C5)O1)=O

InChI

1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

InChI 密鑰

BCFGMOOMADDAQU-UHFFFAOYSA-N

基因資訊

human ... EGFR(1956) , ERBB2(2064)

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生化／生理作用

拉帕替尼(lapatinb)是针对表皮生长因子受体(EGFR/ErbB1)和人表皮生长因子受体2(HER2/ErbB2)的双酪氨酸激酶抑制剂。它与三磷酸腺苷(ATP)竞争酪氨酸激酶结构域上的结合位点。已有研究表明拉帕替尼参与乳腺、肺、外阴、胃和头颈癌等多种人癌细胞中的体外生长抑制和凋亡诱导。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H319,H362,H413

危險分類

Aquatic Chronic 4 - Eye Irrit. 2 - Lact.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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