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Merck
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Key Documents

SML2082

Sigma-Aldrich

Scrambled 10Panx1 trifluoroacetate salt

≥98% (HPLC)

别名:

10PanxSCR TFA, FSVYWAQADR TFA, L-phenylalanyl-L-seryl-L-valyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-alanyl-L-a-aspartyl-L-arginine TFA, Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg TFA, SCPanx, TFA, Scrambled 10Panx TFA

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About This Item

经验公式(希尔记法):
C58H79N15O16 · xC2HF3O2
分子量:
1242.34 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

film (Colorless)

顏色

white to off-white

運輸包裝

wet ice

儲存溫度

−20°C

InChI

1S/C58H79N15O16/c1-29(2)47(73-55(86)44(28-74)72-50(81)37(59)23-32-11-6-5-7-12-32)56(87)71-41(24-33-16-18-35(75)19-17-33)53(84)70-42(25-34-27-64-38-14-9-8-13-36(34)38)52(83)66-30(3)48(79)67-39(20-21-45(60)76)51(82)65-31(4)49(80)69-43(26-46(77)78)54(85)68-40(57(88)89)15-10-22-63-58(61)62/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,82)(H,66,83)(H,67,79)(H,68,85)(H,69,80)(H,70,84)(H,71,87)(H,72,81)(H,73,86)(H,77,78)(H,88,89)(H4,61,62,63)

InChI 密鑰

VNQGVHMGXBRHRA-UHFFFAOYSA-N

生化/生理作用

SCPanx (10PanxSCR) corresponds to the scrambled version of the pannexin-1 (panx1) inhibitor peptide 10panx1 and serves as a negative control peptide in pannexin-1 inhibitory studies involving 10panx1 treatment both in vitro and in vivo.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Paul W Furlow et al.
Nature cell biology, 17(7), 943-952 (2015-06-23)
During metastatic progression, circulating cancer cells become lodged within the microvasculature of end organs, where most die from mechanical deformation. Although this phenomenon was first described over a half-century ago, the mechanisms enabling certain cells to survive this metastasis-suppressive barrier
Nicholas L Weilinger et al.
Nature neuroscience, 19(3), 432-442 (2016-02-09)
Overactivation of neuronal N-methyl-D-aspartate receptors (NMDARs) causes excitotoxicity and is necessary for neuronal death. In the classical view, these ligand-gated Ca(2+)-permeable ionotropic receptors require co-agonists and membrane depolarization for activation. We report that NMDARs signal during ligand binding without activation
C Yi et al.
Cell death and differentiation, 23(10), 1691-1701 (2016-07-09)
In Alzheimer's disease (AD), astrocyte properties are modified but their involvement in this pathology is only beginning to be appreciated. The expression of connexins, proteins forming gap junction channels and hemichannels, is increased in astrocytes contacting amyloid plaques in brains
Roger J Thompson et al.
Science (New York, N.Y.), 322(5907), 1555-1559 (2008-12-06)
Pannexin-1 (Px1) is expressed at postsynaptic sites in pyramidal neurons, suggesting that these hemichannels contribute to dendritic signals associated with synaptic function. We found that, in pyramidal neurons, N-methyl-d-aspartate receptor (NMDAR) activation induced a secondary prolonged current and dye flux
Nicole E Burma et al.
Nature medicine, 23(3), 355-360 (2017-01-31)
Opiates are essential for treating pain, but termination of opiate therapy can cause a debilitating withdrawal syndrome in chronic users. To alleviate or avoid the aversive symptoms of withdrawal, many of these individuals continue to use opiates. Withdrawal is therefore

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