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Merck

SML1654

Sigma-Aldrich

R-酮咯酸

≥95% (HPLC)

别名:

(+)-酮咯酸, (1R)-5-苯甲酰基-2,3-二氢-1H-吡咯烷嗪-1-羧酸;, (R)-酮咯酸, (R)-(+)-酮咯酸

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About This Item

经验公式(希尔记法):
C15H13NO3
CAS号:
分子量:
255.27
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥95% (HPLC)

形狀

powder

光學活性

[α]/D +162 to +178°, c = 1 in methanol

顏色

white to beige

溶解度

DMSO: 25 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

O=C(O)[C@H]1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1

InChI

1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m1/s1

InChI 密鑰

OZWKMVRBQXNZKK-LLVKDONJSA-N

生化/生理作用

R-酮咯酸是Rho家族GTPases Cdc42(细胞分裂控制蛋白42)和Rac1(与Ras相关的C3肉毒杆菌毒素底物1)的一种有效选择性的变构抑制剂,可调节对肿瘤转移至关重要的下游GTPase依赖性生理反应。 R-酮咯酸可显著抑制卵巢癌细胞的粘附、迁移和侵袭。
酮咯酸((rac)-5-苯甲酰基-1,2-3H-吡咯并[1,2a]吡咯1-羧酸)是一种非甾体类抗炎药(NSAID)。它被用作外消旋混合物,其包含1:1的R(+)和S(−)立体异构体。它被广泛用于儿童的肠外镇痛药。酮咯酸可用作非麻醉性镇痛药。它可阻止中枢神经系统外围的前列腺素的合成。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Tudor I Oprea et al.
Drug discovery today. Therapeutic strategies, 8(3-4), 61-69 (2012-03-01)
Academia and small business research units are poised to play an increasing role in drug discovery, with drug repurposing as one of the major areas of activity. Here we summarize project status for a number of drugs or classes of
Enantiomer?selective pharmacokinetics and metabolism of ketorolac in children.
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The pharmacokinetics of ketorolac enantiomers following intramuscular administration of the racemate.
Hayball PJ, et al.
British Journal of Clinical Pharmacology, 37(1), 75-78 (1994)
Yuna Guo et al.
Molecular cancer therapeutics, 14(10), 2215-2227 (2015-07-25)
Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) are attractive therapeutic targets in ovarian cancer based on established importance in tumor cell migration, adhesion, and invasion. Despite a predicted benefit, targeting GTPases has not
Tudor I Oprea et al.
PloS one, 10(11), e0142182-e0142182 (2015-11-13)
Rho family GTPases (including Rac, Rho and Cdc42) collectively control cell proliferation, adhesion and migration and are of interest as functional therapeutic targets in numerous epithelial cancers. Based on high throughput screening of the Prestwick Chemical Library® and cheminformatics we

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