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Merck
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主要文件

SML0888

Sigma-Aldrich

Sertaconazole nitrate

≥98% (HPLC)

别名:

1-[2-[(7-Chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate

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About This Item

经验公式（希尔记法）:
C20H15Cl3N2OS · HNO3
CAS号:
99592-39-9
分子量:
500.78
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C20H15Cl3N2OS.HNO3/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22;2-1(3)4/h1-8,11-12,19H,9-10H2;(H,2,3,4)

InChI 密鑰

HAAITRDZHUANGT-UHFFFAOYSA-N

生化／生理作用

Sertaconazole nitrate is an antifungal agent with anti-inflammatory and anti-itch activity. Topical administration of this drug reduces the releases of cytokines from activated T-cell enriched human lymphocytes. Sertaconazole nitrate has been used as a highly safe and effective therapeutic for treating tinea pedis interdigitalis. It is also used to treat contact hypersensitivity and irritant contact dermatitis.
Sertaconazole nitrate is an imidazole antifungal. Like other imidazole antifungals, sertaconazole blocks the synthesis of ergosterol, an essential component of the fungal cell membrane, by inhibiting the P450 enzyme 14α-demethylase that converts lanosterol to ergosterol.

象形圖

Health hazard
GHS08

訊號詞

Warning

危險聲明

H361d

危險分類

Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Frank Liebel et al.
Archives of dermatological research, 298(4), 191-199 (2006-07-27)
Cutaneous fungal infections are frequently associated with an inflammatory component including irritated skin, itching and stinging/burning. Therapeutic anti-fungal agents that have anti-inflammatory activity have the potential to provide clinical benefit beyond fungus eradication. Recently, certain anti-fungal agents have been shown
Safety and efficacy of sertaconazole nitrate cream 2% in the treatment of tinea pedis interdigitalis: a subgroup analysis.
Borelli C, et al.
Cutis; Cutaneous Medicine for the Practitioner, 85(2), 107-111 (2010)
Anti-Inflammatory Activity of Sertaconazole Nitrate Is Mediated via Activation of a p38?COX-2?PGE2 Pathway.
Sur R, et al.
The Journal of Investigative Dermatology, 128(2), 336-344 (2008)

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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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