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生物源
Radix peucedani
品質等級
化驗
≥97% (HPLC)
形狀
powder
光學活性
[α]/D +120 to +160°, c = 0.5 in chloroform-d
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear
運輸包裝
wet ice
儲存溫度
−20°C
InChI
1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
InChI 密鑰
CUKSFECWKQBVED-INIZCTEOSA-N
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生化／生理作用
Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.
特點和優勢
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jin Sook Song et al.
Xenobiotica; the fate of foreign compounds in biological systems, 41(10), 895-902 (2011-06-11)
Decursinol is a major coumarin derived from the roots of Angelica gigas and has various pharmacological effects against inflammation, angiogenesis, nociceptive pain and Alzheimer's disease. In vitro and in vivo studies were conducted to characterize the metabolism and pharmacokinetics of
Jung-woo Chae et al.
Journal of ethnopharmacology, 144(2), 248-254 (2012-09-18)
Decursin is used as a traditional Asian medicine to treat various women's diseases. Herb-drug interaction has become a serious problem since herbal medicine is extensively used in the modern world. This study investigates effects of decursin, on the pharmacokinetics of
Sa-Ra Choi et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(10), 2517-2523 (2011-06-23)
Decursin is a major biological active component of Angelicagigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. However, the apoptotic mechanism of decursin using primary malignant tumor (RC-58T/h/SA#4)-derived human prostate cells is not known. In the
Nam Il Park et al.
Molecular biotechnology, 50(2), 114-120 (2011-06-01)
Angelica gigas is a medicinal plant that produces pyranocoumarins, including decursin (D) and decursinol angelate (DA), which have neuroprotective, anticancer, and antiandrogenic effects. In this study, the coumarin biosynthetic pathway was engineered to increase the production of DA. Specifically, a
In Sik Kim et al.
Molecular biology reports, 40(3), 2541-2548 (2013-01-08)
(S)-(+)-decursin is a biological coumarin compound isolated from Angelica gigas Nakai. (S)-(+)-decursin and its analogue have a variety of pharmacological activities. In the present study, the anti-inflammatory effect of a (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano [3,2-g]-chromen-3-yl-ester (Compound 6, C6), on
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We offers many products related to Nuclear Receptors (Steroids) for your research needs.
We offers many products related to Nuclear Receptors (Steroids) for your research needs.
We offers many products related to Nuclear Receptors (Steroids) for your research needs.
We offers many products related to Nuclear Receptors (Steroids) for your research needs.
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