SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

• 别名: 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
• 经验公式（希尔记法）: C₁₆H₁₉N₃O₃ · 2HCl
• CAS号: 32434-42-7
• 分子量: 374.26
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329825583
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 光學活性: [α]/D 10 to 15°, c = 1 in H₂O
• 儲存條件: desiccated
• 顏色: off-white to gray-brown
• 溶解度: H₂O: 15 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
• InChI: 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
• InChI 密鑰: SNTOTCUGCWLHEZ-KKJWGQAZSA-N

说明

生化／生理作用

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable