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SML0309

Sigma-Aldrich

苯基丁酸钠

≥98% (HPLC)

别名:

4-PBA, 4-苯丁酸钠, 4-苯基丁酸, 4-苯基丁酸钠, 三酷酸酯, 苯丁酸钠制剂

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About This Item

经验公式（希尔记法）:
C10H11NaO2
CAS号:
1716-12-7
分子量:
186.18
MDL编号:
MFCD00800247
UNSPSC代码:
12352200
PubChem化学物质编号:
329825314
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

H2O: ≥5 mg/mL

储存温度

room temp

SMILES字符串

[Na+].[O-]C(=O)CCCc1ccccc1

InChI

1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1

InChI key

VPZRWNZGLKXFOE-UHFFFAOYSA-M

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一般描述

苯基丁酸钠刺激尿中氮元素排出。它是一种前体药物，经过 β-氧化后形成乙酸苯酯。苯基丁酸钠用于处理尿素循环疾病。它可能和月经失调，闭经和食管和胃的疼痛性粘膜炎有关。

应用

苯基丁酸钠用于作为内质网（ER）压力抑制物，用来研究ER压力在 betatrophin表达中的作用。

生化/生理作用

苯基丁酸钠是一种组蛋白去乙酰化酶抑制剂。

特点和优势

该化合物是基因调控研究的特色产品。点击此处以了解更多的基因调控特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000385496
0000385496
0000267840
0000263281
0000228052

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Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
Lee B, et al.
Molecular Genetics and Metabolism, 100(3), 221-228 (2010)
Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies
Lee YH, et al.
Scientific Reports, 6(3), 24013-24013 (2016)
The Molecular and Genetic Basis of Neurologic and Psychiatric Disease (2008)
Advances in Clinical Chemistry, Volume 17 (2014)
Kyoungsub Song et al.
Hepatology (Baltimore, Md.), 58(5), 1681-1692 (2013-05-25)
MicroRNA-122 (miR-122), a pivotal liver-specific miRNA, has been implicated in several liver diseases including hepatocellular carcinoma (HCC) and hepatitis C and B viral infection. This study aimed to explore epigenetic regulation of miR-122 in human HCC cells and to examine
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