SML0224
HI-6
≥98% (HPLC)
别名:
1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride, 4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride, Asoxime chloride, HI 6, HI 6 chloride, HJ 6, Transant
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所有图片(1)
About This Item
经验公式（希尔记法）:
C14H16N4O3 · 2Cl
CAS号:
分子量:
359.21
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
H2O: 15 mg/mL (clear solution)
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1
InChI
1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H
InChI 密鑰
QELSIJXWEROXOE-UHFFFAOYSA-N
一般說明
HI-6 functions as an antidote for treating intoxication caused by nerve agents. It acts as a potent drug in radiation protection and suppresses oxidative stress. HI-6 prevents the toxicity of the antineoplastic drug irinotecan.
生化／生理作用
HI-6 is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model
Pohanka M, et al.
Neuro Endocrinology Letters, 31(2), 62-62 null
Miriam Dadparvar et al.
Toxicology letters, 206(1), 60-66 (2011-07-06)
The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes. However, the blood-brain barrier (BBB) restricts the rapid transport of these drugs from the blood into the brain in therapeutically
Jiri Kassa et al.
Basic & clinical pharmacology & toxicology, 110(4), 322-326 (2011-10-11)
The ability of three newly developed reversible inhibitors of acetylcholinesterase (AChE) (K298, K344 and K474) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was compared. Neither
Reinhard Bogan et al.
Drug testing and analysis, 4(3-4), 199-207 (2012-03-01)
As reactivators of inhibited acetylcholinesterase, oximes are essential antidotes in poisoning by organophosphorus compounds. Due to its superior efficacy in cases of soman, cyclosarin, and sarin poisoning, the oxime HI-6 represents a promising option for an active pharmaceutical ingredient (API)
Reinhard Bogan et al.
Drug testing and analysis, 4(3-4), 208-214 (2012-02-24)
HI-6 exhibits superior efficacy in the therapy of intoxication by different highly toxic organophosphorus nerve agents. Therefore HI-6 is a promising candidate for the development of new antidotes against nerve agents. For ethical and safety reasons antidotes containing HI-6 should
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