SML0204

MS-1020

≥98% (HPLC)

• 别名: 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphtamide, 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
• 经验公式（希尔记法）: C₂₁H₁₈N₂O₃
• CAS号: 1255516-86-9
• 分子量: 346.38
• UNSPSC代码: 12352202
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to tan
• 溶解性: DMSO: ≥10 mg/mL at 60 °C
• 储存温度: 2-8°C

说明

应用

MS-1020 may be used in JAK-3-mediated cell signaling studies.

生化/生理作用

MS-1020 is a selective JAK3 inhibitor

MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression.

特点和优势

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302,H319
• 预防措施声明: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• 危险分类: Acute Tox. 4 Oral - Eye Irrit. 2
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable