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SML0100

Sigma-Aldrich

GYY4137二氯甲烷配合物

≥98% (HPLC), powder, H₂S donor

别名:

与吗啉（1:1）形成的化合物, 吗啉-4-鎓4-甲氧基苯基(吗啉代)二硫代磷酸二氯甲烷配合物, 对-(4-甲氧基苯基)-P-4-吗啉基-二硫代磷酸

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About This Item

经验公式（希尔记法）:
C11H16NO2PS2 · C4H9NO · xCH2Cl2
CAS号:
106740-09-4
分子量:
376.47
分類程式碼代碼:
12352200
PubChem物質ID:
329825158
NACRES:
NA.25

产品名称

GYY4137二氯甲烷配合物, ≥98% (HPLC)

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: ≥3 mg/mL

儲存溫度

2-8°C

SMILES 字串

ClCCl.S=P(N1CCOCC1)([S-])C2=CC=C(OC)C=C2.C3COCC[NH2+]3

InChI

1S/C11H16NO2PS2.C4H9NO.CH2Cl2/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1;2-1-3/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2;1H2

InChI 密鑰

PKLNNEJKTAMITC-UHFFFAOYSA-N

應用

GYY4137二氯甲烷配合物一直用作非异硫氰酸酯H2S（硫化氢）供体。

生化／生理作用

GYY4137是具有血管扩张和抗高血压活性的H2S的小分子释放剂。H2S是一种重要的生物介质，对神经调节、高血压、炎症和血管张力具有多重作用。 GY4137应该可以用于研究H2S的多种生物效应。
小分子H2S释放剂

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000198420
0000157494
0000157494
0000198420
0000139870

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Jiateng Hu et al.
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Critical limb ischemia, the final course of peripheral artery disease, is characterized by an insufficient supply of blood flow and excessive oxidative stress. H2 S molecular therapy possesses huge potential for accelerating revascularization and scavenging intracellular reactive oxygen species (ROS).
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Diabetic retinopathy is a progressive disease, and one of the key metabolic abnormalities in the pathogenesis of diabetic retinopathy, mitochondrial damage, is also influenced by the duration of hyperglycemia. Mitochondrial quality control involves a coordination of mitochondrial dynamics, biogenesis and
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Hyperhomocysteinaemia (HHcy)-impaired endothelial dysfunction including endoplasmic reticulum (ER) stress plays a crucial role in atherogenesis. Hydrogen sulphide (H2 S), a metabolic production of Hcy and gasotransmitter, exhibits preventing cardiovascular damages induced by HHcy by reducing ER stress, but the underlying
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