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Merck
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Key Documents

SCP0159

Sigma-Aldrich

Granzyme B Substrate / Caspase 3 Processing Enzyme Substrate / Caspase 8 Processing Enzyme Substrate

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About This Item

经验公式(希尔记法):
C33H42N6O13
分子量:
730.72
分類程式碼代碼:
12352204
NACRES:
NA.32

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥85%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Z-Ile-Glu-Thr-Asp-pNA

應用

Caspase 8 Processing Enzyme Substrate (Z-Ile-Glu-Thr-Asp-pNA; zIETD-pNa) is used as a substrate to identify, differentiate and characterize Granzyme B, Caspase 3 Processing Enzyme(s) and Caspase 8 Processing enzyme(s). Z-Ile-Glu-Thr-Asp-pNA is closely related to Z-Ile-Glu-Thr-Asp-fluoromethylketone (zIETD-fmk), an inhibitor of Caspase 8.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mohammed W Al-Rabia et al.
Journal of leukocyte biology, 75(6), 1045-1055 (2004-04-13)
Caspases are key molecules in the control of apoptosis, but relatively little is known about their contribution to eosinophil apoptosis. We examined caspase-3, -8, and -9 activities in receptor ligation-dependent apoptosis induction in the differentiated human eosinophilic cell line EoL-1.
Christopher E Jenkins et al.
The Journal of biological chemistry, 279(35), 37201-37207 (2004-06-19)
Mast cells play an important role in both allergy and innate immunity. Recently, we demonstrated an active interaction between human mast cells and Pseudomonas aeruginosa leading to the production of multiple cytokines. Here, we show that both primary cultured human
W D Thomas et al.
Journal of immunology (Baltimore, Md. : 1950), 165(10), 5612-5620 (2000-11-09)
Past studies have shown that TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis in a high proportion of cultured melanoma by caspase-dependent mechanisms. In the present studies we have examined whether TRAIL-induced apoptosis of melanoma was mediated by direct activation of effector

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