推荐产品
product name
Caspase 3 Substrate,
化驗
≥95% (HPLC)
形狀
lyophilized
成份
Peptide Content, ≥80%
儲存條件
protect from light
儲存溫度
−20°C
Amino Acid Sequence
Ac-Asp-Glu-Val-Asp-4M2NA
一般說明
Caspase 3 belongs to the family of cysteinyl proteases, which regulate apoptosis. It is encoded by CASP-3 gene. Caspase 3 is important for normal brain development. Caspase 3 is involved in growth stimulation of surviving tumor cells. It is associated with neuronal apoptosis in Alzheimer′s disease.
應用
Caspase 3 Substrate has been used to determine caspase activity in esophageal squamous cell carcinoma EC109 cell line.
Caspase 3, a cysteine protease activator of caspase 6 and caspase 7, metabolizes amyloid-β 4A precursor protein. Caspase 3 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the DxxD (asp-x-x-asp) sequences DMQD and DEVD such as Ac-DMQD-pNa (Acetyl-Asp-Met-Gln-Asp-p- nitroanalide), chromogenic; Ac-DMQD-AMC (Acetyl-Asp-Met-Gln-Asp- amino-4-methylcoumarin), fluorogenic and Ac-DEVD-4M2Na.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease
Louneva N, et al.
The American Journal of Pathology, 173(5), 1488-1495 (2008)
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis
Kothakota S, et al.
Science, 278(5336), 294-298 (1997)
Emerging roles of caspase-3 in apoptosis
Porter AG and Janicke RU
Cell Death and Differentiation, 6(2), 99-99 (1999)
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
Huang Q, et al.
Nature Medicine, 17(7), 860-860 (2011)
Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma
Tang Q, et al.
Cancer Letters, 336(2), 325-337 (2013)
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