SAB4700108

Monoclonal Anti-CD19 antibody produced in mouse

clone 4G7, purified immunoglobulin, buffered aqueous solution

• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 4G7, monoclonal
• 形狀: buffered aqueous solution
• 物種活性: human
• 技術: flow cytometry: suitable
• 同型: IgG1
• NCBI登錄號: NM_001178098.1
• UniProt登錄號: P15391
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CD19(930)

说明

一般說明

CD19 (cluster of differentiation 19) is a 95kDa protein localized on the surface of nearly all B lymphocytes and is considered to be the specific surface marker for B cells.This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of ∼240 amino acids and is involved in the regulation of B cell function.The protein is encoded by the 7.41kb cd19 gene, mapped on the short arm of human chromosome 16p11.2. There are certain localized regions of strong net negative charges with nine tyrosine residues in the cytoplasmic region of CD19. These regions might regulate the interaction of CD19 with the proto-oncogene Vav, phosphatidylinositol-3 kinase (PI-3 kinase) and the Lyn, Lck and Fyn protein tyrosine kinases.

免疫原

Human CCL (chronic lymphocytic leukemia) cells

應用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化／生理作用

CD19 (cluster of differentiation 19) expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen.The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable